A current publication by the European Medicines Agency (EMA) states that the use of ivermectin for the prevention or treatment of Covid-19 cannot currently be recommended outside of controlled clinical studies. More randomized studies are needed to show that the drug is effective and safe.
Toxicity at high doses cannot be excluded
The EMA had previously reviewed the most recent studies and meta-analyzes on ivermectin. This shows that the active ingredient can block the reproduction of the SARS-CoV-2 pathogen, but only at significantly higher concentrations, it is said. He continued: “The results of the clinical trials were mixed. Some studies showed no benefit, others reported a possible benefit. Most of the studies examined by the EMA were small and had additional limitations, including different dosage regimens and the use of concomitant drugs. […]”Although ivermectin is generally well tolerated at the doses approved for other indications, side effects may be increased at the much higher doses required to achieve effective concentrations of ivermectin in the lungs against the virus. Toxicity when used Ivermectin in higher than the approved doses could therefore not be ruled out.
Hyped as a miracle drug in the Czech Republic
Ivermectin has been on everyone’s lips for weeks, especially in the Czech Republic. Its reputation as a miracle cure was fueled by various Internet reports of Covid-19 patients being cured. At the beginning of March, the Czech Prime Minister Andrej Babiš announced at a press conference that they would not wait for clinical studies but try to apply them. The Ministry of Health in Prague then issued a time-limited approval for a drug based on ivermectin. Despite the EMA’s assessment, the agency has not changed its stance on ivermectin.
Health Minister Jan Blatný affirmed that it was still permitted in the Czech Republic under strict conditions. “It is a drug that has been approved for experimental therapy in the Czech Republic and, as such, is subject to strict requirements and regulations. It is not a drug that patients should obtain on their own initiative. It is not suitable for everyone. It is not a panacea. ” The State Medicines Inspectorate in the Czech Republic has not yet had enough data for this.
Since March 12, doctors in the Czech Republic have been allowed to use ivermectin in patients. The prerequisite is, among other things, appropriate medical information and the consent of the person being treated.
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